Gabapentin for Neuropathic Pain

About

This repository contains all the files required to generate the application (and supporting documents) the International Association for the Study of Pain (IASP) and the International Association of Hospice and Palliative Care (IAHPC) made to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines (2017) for the inclusion of gabapentin on the WHO Model List of Essential Medicines for the treatment of neuropathic pain.

For a brief summary of why we have applied for the inclusion of an additional medicine to treat neuropathic pain on the WHO Model List, see:

• Neuropathic pain: so many people, but where are the drugs?
• World Health Organization essential medicines lists: where are the drugs to treat neuropathic pain? PAIN 156:793-797, 2015. DOI: 10.1097/01.j.pain.0000460356.94374.a1, PMC: 4670621

Citation

Kamerman PR, Finnerup NB, De Lima L, Haroutounian S, Raja SN, Rice ASC, Smith BH, Treede RD. Gabapentin for neuropathic pain: An application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines. DOI: 10.6084/m9.figshare.3814206.v2, 2016

Acknowledgements

We are indebted to our four external reviewers for their constructive comments:

• Michael I Bennett (UK)
• Daniel Ciampi de Andrada (Brazil)
• G Allen Finley (Canada)
• Telesphore B Nguelefack (Cameroon)

We also thank Dr Nicola Magrini (Secretary of the Expert Committee on the Selection and Use of Essential Medicines) and Dr Tarun Dua (Department of Mental Health and Substance Abuse) for their assistance and constructive feedback.

Instructions

Download a complete copy

Click on this link to access a PDF of the complete document (application and appendices).

Build the document

Follow the steps below to compile the application, appendices, and the executive summary.

Windows users must first download and install:

• Git for Windows or any other Bash-like shell for Windows.

• GNU Make.

If you use Git/GitHub:

1. Fork the repository to your GitHub account.

2. Clone the repository to your computer.

3. Open a terminal and change the path to the directory of the respository.

4. Type 'make'.

If you do not use Git/GitHub:

1. Download the repository as a zip file.

2. Unzip the repository on your computer.

3. Open a terminal and change the path to the directory you unzipped the repository into.

4. Type 'make'.

The following set-up was used to generate all files

• R version 3.3.1 (2016-06-21) running on RStudio v1.0.44 for macOS Sierra
• Packages used (inclusive of: application.Rmd, appendices.Rmd, summary.Rmd, and all other analysis scripts):
  • cowplot 0.7.0
  • dplyr 0.5.0
  • ggplot2 2.2.0
  • gridExtra 2.2.1
  • knitr 1.15
  • pander 0.6.0
  • readr 1.0.0
  • rmeta 2.16
  • scales 0.4.1
  • stringr 1.1.0
  • tidyr 0.6.0
  • xtable 1.8-2

License

Gabapentin for neuropathic pain: An application to the 21st meeting of the WHO Expert Committee on Selection and Use of Essential Medicines for the inclusion of gabapentin on the WHO Model List of Essential Medicines by the International Association for the Study of Pain (IASP) and the International Association of Hospice and Palliative Care (IAHPC) is licensed under a Creative Commons Attribution 4.0 International License.